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lin28a inhibitor c1632  (MedChemExpress)


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    MedChemExpress lin28a inhibitor c1632
    Lin28a Inhibitor C1632, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lin28a+inhibitor+c1632/Lin28-let-7+antagonist+1/pm41850661-67-4-9
    Average 94 stars, based on 2 article reviews
    lin28a inhibitor c1632 - by Bioz Stars, 2026-10
    94/100 stars

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    Injection:

    Article Title: Lin28A Drives hepatic fibrosis by suppressing HMGA2/HIF-1α-Dependent ferroptosis in hepatic stellate cells.
    Article Snippet: Effective therapies for liver fibrosis are lacking.. The RNA-binding protein Lin28A is upregulated in human cirrhotic and mouse fibrotic livers, where it localizes to activated hepatic stellate cells (HSCs).. HSCs-specific overexpression of Lin28A worsened carbon tetrachloride (CCl4)-induced fibrosis in mice.



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    lin28a inhibitor c1632  (MedChemExpress)
    94
    MedChemExpress lin28a inhibitor c1632
    Lin28a Inhibitor C1632, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lin28a+inhibitor+c1632/Lin28-let-7+antagonist+1/pm41850661-67-4-9
    Average 94 stars, based on 1 article reviews
    lin28a inhibitor c1632 - by Bioz Stars, 2026-10
    94/100 stars
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    lin28a inhibitor c1632  (Cayman Chemical)
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    Cayman Chemical lin28a inhibitor c1632
    Let-7i-5p downregulated target gene <t>Lin28a</t> . ( A ) The potential target genes of let-7i-5p were predicted using the miRDB, TargetScan, and miRWalk databases. ( B ) The binding affinity of let-7i-5p with Lin28a 3’-UTR measured by dual-luciferase reporter assays. ( C ) The levels of miRNA let-7i-5p in NPCs. ( D ) The mRNA levels of Lin28a in NPCs. ( E ) Representative WB graphs of LIN28A in NPCs. ( F ) The levels of miRNA let-7i-5p in NPCs. ( G ) The mRNA levels of Lin28a in NPCs. ( H ) Representative WB graphs of LIN28A in NPCs. ( I ) IHC staining for LIN28A in rat coccygeal IVD tissues injected with MΦ-sEVs. ( J ) IHC staining for LIN28A in rat lumbar IVD tissues with different ages. ( K ) IHC staining for LIN28A in rat coccygeal IVD tissues with different ages. (NS: not significant, * P < 0.05, ** P < 0.01, *** P < 0.001, n = 5 in B-H, n = 6 in I-K).
    Lin28a Inhibitor C1632, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lin28a+inhibitor+c1632/c1632+n+methyl+n++3++3+methyl+1+2+4+triazolo+4+3+b+pyridazin+6+yl+phenyl+acetamide/pmc11846513-48-1-4
    Average 90 stars, based on 1 article reviews
    lin28a inhibitor c1632 - by Bioz Stars, 2026-10
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    Let-7i-5p downregulated target gene Lin28a . ( A ) The potential target genes of let-7i-5p were predicted using the miRDB, TargetScan, and miRWalk databases. ( B ) The binding affinity of let-7i-5p with Lin28a 3’-UTR measured by dual-luciferase reporter assays. ( C ) The levels of miRNA let-7i-5p in NPCs. ( D ) The mRNA levels of Lin28a in NPCs. ( E ) Representative WB graphs of LIN28A in NPCs. ( F ) The levels of miRNA let-7i-5p in NPCs. ( G ) The mRNA levels of Lin28a in NPCs. ( H ) Representative WB graphs of LIN28A in NPCs. ( I ) IHC staining for LIN28A in rat coccygeal IVD tissues injected with MΦ-sEVs. ( J ) IHC staining for LIN28A in rat lumbar IVD tissues with different ages. ( K ) IHC staining for LIN28A in rat coccygeal IVD tissues with different ages. (NS: not significant, * P < 0.05, ** P < 0.01, *** P < 0.001, n = 5 in B-H, n = 6 in I-K).

    Journal: International Journal of Nanomedicine

    Article Title: MiRNA Let-7i-5p-Contained Small Extracellular Vesicles from Macrophages Induce Nucleus Pulposus Cell Senescence via Targeting LIN28A

    doi: 10.2147/IJN.S482646

    Figure Lengend Snippet: Let-7i-5p downregulated target gene Lin28a . ( A ) The potential target genes of let-7i-5p were predicted using the miRDB, TargetScan, and miRWalk databases. ( B ) The binding affinity of let-7i-5p with Lin28a 3’-UTR measured by dual-luciferase reporter assays. ( C ) The levels of miRNA let-7i-5p in NPCs. ( D ) The mRNA levels of Lin28a in NPCs. ( E ) Representative WB graphs of LIN28A in NPCs. ( F ) The levels of miRNA let-7i-5p in NPCs. ( G ) The mRNA levels of Lin28a in NPCs. ( H ) Representative WB graphs of LIN28A in NPCs. ( I ) IHC staining for LIN28A in rat coccygeal IVD tissues injected with MΦ-sEVs. ( J ) IHC staining for LIN28A in rat lumbar IVD tissues with different ages. ( K ) IHC staining for LIN28A in rat coccygeal IVD tissues with different ages. (NS: not significant, * P < 0.05, ** P < 0.01, *** P < 0.001, n = 5 in B-H, n = 6 in I-K).

    Article Snippet: The LIN28A inhibitor C1632 (Cayman, Ann Arbor, MI, USA) or siRNAs were used to evaluate the role of LIN28A in NPC senescence.

    Techniques: Binding Assay, Luciferase, Immunohistochemistry, Injection

    Let-7i-5p inhibitor ameliorated NPC senescence induced by MΦ-sEVs. ( A ) Typical photomicrographs of senescent NPCs labeled with SA-β-Gal. ( B ) The mRNA levels of Lin28a, Il1a, Il1b, Il6, Ccl2, Ccl5, Tnf, Mmp3 , and Mmp13 in NPCs. ( C ) Representative WB graphs of LIN28A, p16, p21, p53, Collagen II, SOX9, and MMP13 in NPCs. (NS: not significant, * P < 0.05, ** P < 0.01, *** P < 0.001, n = 5).

    Journal: International Journal of Nanomedicine

    Article Title: MiRNA Let-7i-5p-Contained Small Extracellular Vesicles from Macrophages Induce Nucleus Pulposus Cell Senescence via Targeting LIN28A

    doi: 10.2147/IJN.S482646

    Figure Lengend Snippet: Let-7i-5p inhibitor ameliorated NPC senescence induced by MΦ-sEVs. ( A ) Typical photomicrographs of senescent NPCs labeled with SA-β-Gal. ( B ) The mRNA levels of Lin28a, Il1a, Il1b, Il6, Ccl2, Ccl5, Tnf, Mmp3 , and Mmp13 in NPCs. ( C ) Representative WB graphs of LIN28A, p16, p21, p53, Collagen II, SOX9, and MMP13 in NPCs. (NS: not significant, * P < 0.05, ** P < 0.01, *** P < 0.001, n = 5).

    Article Snippet: The LIN28A inhibitor C1632 (Cayman, Ann Arbor, MI, USA) or siRNAs were used to evaluate the role of LIN28A in NPC senescence.

    Techniques: Labeling

    Inhibiting or silencing LIN28A induced NPC senescence. ( A ) Typical photomicrographs of senescent NPCs labeled with SA-β-Gal. ( B ) The viability of NPCs measured by CCK-8 assays. ( C ) The mRNA levels of Il1a, Il1b, Il6, Ccl2, Ccl5, Tnf, Mmp3, Mmp13, Col2a1 , and Acan in NPCs. ( D ) Representative WB graphs of LIN28A, p16, p21, p53, Collagen II, SOX9, and MMP13 in NPCs. ( E ) The mRNA levels of Lin28a in NPCs. ( F ) Typical photomicrographs of senescent NPCs labeled with SA-β-Gal. ( G ) The mRNA levels of Il1a, Il1b, Il6, Ccl2, Ccl5, Tnf, Mmp3, Mmp13, Col2a1 , and Acan in NPCs. ( H ) Representative WB graphs of LIN28A, p16, p21, p53, Collagen II, SOX9, and MMP13 in NPCs. (NS: not significant, * P < 0.05, ** P < 0.01, *** P < 0.001, n = 5).

    Journal: International Journal of Nanomedicine

    Article Title: MiRNA Let-7i-5p-Contained Small Extracellular Vesicles from Macrophages Induce Nucleus Pulposus Cell Senescence via Targeting LIN28A

    doi: 10.2147/IJN.S482646

    Figure Lengend Snippet: Inhibiting or silencing LIN28A induced NPC senescence. ( A ) Typical photomicrographs of senescent NPCs labeled with SA-β-Gal. ( B ) The viability of NPCs measured by CCK-8 assays. ( C ) The mRNA levels of Il1a, Il1b, Il6, Ccl2, Ccl5, Tnf, Mmp3, Mmp13, Col2a1 , and Acan in NPCs. ( D ) Representative WB graphs of LIN28A, p16, p21, p53, Collagen II, SOX9, and MMP13 in NPCs. ( E ) The mRNA levels of Lin28a in NPCs. ( F ) Typical photomicrographs of senescent NPCs labeled with SA-β-Gal. ( G ) The mRNA levels of Il1a, Il1b, Il6, Ccl2, Ccl5, Tnf, Mmp3, Mmp13, Col2a1 , and Acan in NPCs. ( H ) Representative WB graphs of LIN28A, p16, p21, p53, Collagen II, SOX9, and MMP13 in NPCs. (NS: not significant, * P < 0.05, ** P < 0.01, *** P < 0.001, n = 5).

    Article Snippet: The LIN28A inhibitor C1632 (Cayman, Ann Arbor, MI, USA) or siRNAs were used to evaluate the role of LIN28A in NPC senescence.

    Techniques: Labeling, CCK-8 Assay